E-COMPARED aims to provide mental healthcare stakeholders with evidence-based information and recommendations about the clinical and cost-effectiveness of blended depression treatment. Comparative Effectiveness Research is conducted in nine European countries to determine what treatment works best, for whom, and under what circumstances. Current practice of Cognitive Behavioural Therapy (CBT) in routine and specialised mental healthcare is compared with ‘blended’ treatment for depression that combines both internet, mobile technologies, and face-to-face interventions. To achieve this, the E-COMPARED consortium pursues the following objectives: